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Article

Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.

Nature genetics - 1 Jun 1995

Tournamille C, Colin Y, Cartron J P, Le Van Kim C

Abstract excerpt

The mRNA for the Duffy blood group antigen, the erythrocyte receptor for the Plasmodium vivax malaria parasite, has recently been cloned and shown to encode a widely expressed chemokine receptor. Here, we show that the Duffy antigen/chemokine receptor gene (DARC) is composed of a single exon and that most Duffy-negative blacks carry a silent FY*B allele with a single T to C substitution at nucleotide -46. This...

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Source

Identifiers

PMID: 7663520
DOI: 10.1038/ng0695-224

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.PMID 7663520Read ↗

A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.Semantic proximity Read ↗

Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a-b-) phenotype.Semantic proximity Read ↗

Duffy Antigen Expression in Erythroid Bone Marrow Precursor Cells of Genotypically Duffy Negative IndividualsSemantic proximity Read ↗

The Duffy blood group system: a review.Semantic proximity Read ↗

[Molecular basis and structure-activity relationships of the Duffy blood group antigens: chemokine and Plasmodium vivax receptors].Semantic proximity Read ↗

The coding sequence of Duffy blood group gene in humans and simians: restriction fragment length polymorphism, antibody and malarial parasite specificities, and expression in nonerythroid tissues in Duffy-negative individuals.Semantic proximity Read ↗

Differential expression of the duffy antigen receptor for chemokines according to RBC age and FY genotype.Semantic proximity Read ↗

Molecular mechanisms that lead to reduced expression of duffy antigens.Semantic proximity Read ↗

Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.Semantic proximity Read ↗

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.Semantic proximity Read ↗

Determination of Duffy genotypes in three populations of African descent using PCR and sequence-specific oligonucleotides.Semantic proximity Read ↗

Duffy blood group and malariaSemantic proximity Read ↗

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