Article
Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.
Nature genetics - 1 Jun 1995
Tournamille C, Colin Y, Cartron J P, Le Van Kim C
Abstract excerpt
The mRNA for the Duffy blood group antigen, the erythrocyte receptor for the Plasmodium vivax malaria parasite, has recently been cloned and shown to encode a widely expressed chemokine receptor. Here, we show that the Duffy antigen/chemokine receptor gene (DARC) is composed of a single exon and...
Topics
- Antigens, Protozoan
- Base Sequence
- Black People
- Carrier Proteins
- Chromosome Mapping
- DNA-Binding Proteins
- Duffy Blood-Group System
- Erythrocytes
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Gene Expression
- Genotype
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protozoan Proteins
- Receptors, Cell Surface