Article
Identification of ACKR1 variants associated with altered Duffy phenotype expression in blood donors from southern Brazil.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis - 1 Aug 2020
Höher Gabriela, Rodrigues Mirelen Moura de Oliveira, Waskow Gabriela, Agnes Grasiela, Von Burg Pâmela Victoria, Onsten Tor, Fiegenbaum Marilu, Almeida Silvana
Abstract excerpt
The atypical chemokine receptor 1 gene (ACKR1) is responsible for the clinically significant Duffy blood group. The main antigens of this system, Fya and Fyb, can be related to a null or weak expression of the DARC protein. In the present work, we aimed to identify ACKR1 gene variants in blood donors from southern Brazil based on discrepancies between their serological and molecular typing results. Then, we...
Topics
- Base Sequence
- Brazil
- Duffy Blood-Group System
- Humans
- Phenotype
- Receptors, Cell Surface