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Article

The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2006

Lee Janet S, Wurfel Mark M, Matute-Bello Gustavo, Frevert Charles W, Rosengart Matthew R, Ranganathan Mrunalini, Wong Venus W, Holden Tarah, Sutlief Steve, Richmond Ann, Peiper Stephen, Martin Thomas R

Abstract excerpt

The Duffy blood group Ag (dfy) binds selective CXC and CC chemokines at high affinity and is expressed on erythrocytes and endothelial cells. However, it does not transmit a signal via G proteins, as occurs with other seven-transmembrane receptors. We hypothesized that dfy functions as a chemokine reservoir and regulates inflammation by altering soluble chemokine concentrations in the blood and tissue...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17114483
DOI: 10.4049/jimmunol.177.11.8086
PMCID: PMC2665269

Genes

MIP
CCL2
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation.PMID 17114483Read ↗

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Distinct Transcript Isoforms of the Atypical Chemokine Receptor 1 (ACKR1)/Duffy Antigen Receptor for Chemokines (DARC) Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele.Semantic proximity Read ↗

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