Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a-b-) phenotype.

Abstract excerpt

The erythrocyte chemokine receptor, a receptor for Plasmodium vivax, carries the antigens of the Duffy blood group system. Sequence analysis of reticulocyte RNA from individuals of known Duffy phenotype showed that the Fya antigen differs from the Fyb antigen as a result of a single nucleotide difference (A131 or G) encoding amino acid Gly44 (Fya) or Asp (Fyb) in the N-terminal extracellular domain of the...

Topics

• Amino Acid Sequence
• Base Sequence
• Duffy Blood-Group System
• Erythrocytes
• Gene Deletion
• Humans
• Membrane Glycoproteins
• Molecular Sequence Data
• Phenotype
• Polymerase Chain Reaction