Article
DARC alleles and Duffy phenotypes in African Americans.
Transfusion - 1 Jun 2012
Schmid Pirmin, Ravenell Kanaeko R, Sheldon Sherry L, Flegel Willy A
Abstract excerpt
BACKGROUND: The DARC (Duffy blood group, chemokine receptor) gene encodes for a transmembrane glycoprotein that functions as a chemokine transporter, is a receptor for Plasmodium vivax and P. knowlesi, and expresses the Duffy blood group antigens (Fy). The Fy(a-b-) phenotype found in people of African descent is typically associated with a -67t>c mutation in the 5'-untranslated region (UTR), which prevents red...
Topics
- Black or African American
- Alleles
- Animals
- Duffy Blood-Group System
- Gene Frequency
- Genotype
- Humans
- Neanderthals
- Phenotype
- Phylogeny
- Receptors, Cell Surface
- Sequence Analysis, DNA