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Article

DARC alleles and Duffy phenotypes in African Americans.

Transfusion - 1 Jun 2012

Schmid Pirmin, Ravenell Kanaeko R, Sheldon Sherry L, Flegel Willy A

Abstract excerpt

BACKGROUND: The DARC (Duffy blood group, chemokine receptor) gene encodes for a transmembrane glycoprotein that functions as a chemokine transporter, is a receptor for Plasmodium vivax and P. knowlesi, and expresses the Duffy blood group antigens (Fy). The Fy(a-b-) phenotype found in people of African descent is typically associated with a -67t>c mutation in the 5'-untranslated region (UTR), which prevents red...

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Identifiers

PMID: 22082243
DOI: 10.1111/j.1537-2995.2011.03431.x
PMCID: PMC3374024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DARC alleles and Duffy phenotypes in African Americans.PMID 22082243Read ↗

[Molecular basis and structure-activity relationships of the Duffy blood group antigens: chemokine and Plasmodium vivax receptors].Semantic proximity Read ↗

Molecular basis of the Duffy blood group system.Semantic proximity Read ↗

Determination of Duffy genotypes in three populations of African descent using PCR and sequence-specific oligonucleotides.Semantic proximity Read ↗

Species-specific features of DARC, the primate receptor for Plasmodium vivax and Plasmodium knowlesi.Semantic proximity Read ↗

Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria.Semantic proximity Read ↗

Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans.Semantic proximity Read ↗

Identification of ACKR1 variants associated with altered Duffy phenotype expression in blood donors from southern Brazil.Semantic proximity Read ↗

Population Genetic Analysis of the DARC Locus (Duffy) Reveals Adaptation from Standing Variation Associated with Malaria Resistance in HumansSemantic proximity Read ↗

A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.Semantic proximity Read ↗

Analysis for genotyping Duffy blood group in inhabitants of Sudan, the fourth cataract of the Nile.Semantic proximity Read ↗

Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a-b-) phenotype.Semantic proximity Read ↗

[Duffy blood group antigens: structure, serological properties and function].Semantic proximity Read ↗

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