Article
Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia.
PloS one - 1 Jan 2018
Charles Bashira A, Hsieh Matthew M, Adeyemo Adebowale A, Shriner Daniel, Ramos Edward, Chin Kyung, Srivastava Kshitij, Zakai Neil A, Cushman Mary, McClure Leslie A, Howard Virginia, Flegel Willy A, Rotimi Charles N, Rodgers Griffin P
Abstract excerpt
BACKGROUND: Benign ethnic neutropenia (BEN) is a hematologic condition associated with people of African ancestry and specific Middle Eastern ethnic groups. Prior genetic association studies in large population showed that rs2814778 in Duffy Antigen Receptor for Chemokines (DARC) gene, specifically DARC null red cell phenotype, was associated with BEN. However, the mechanism of this red cell phenotype leading to...
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