The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

doi:10.1084/jem.181.4.1311

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Article

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

The Journal of experimental medicine - 1 Apr 1995

Peiper S C, Wang Z X, Neote K, Martin A W, Showell H J, Conklyn M J, Ogborne K, Hadley T J, Lu Z H, Hesselgesser J, Horuk R

Abstract excerpt

The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions not only as a promiscuous chemokine receptor but also as a receptor for the malarial parasite, Plasmodium vivax. The recent finding that DARC is ubiquitously expressed by endothelial cells lining postcapillary venules provides a possible insight into the function of this receptor because this anatomic site is an active...

Topics

Amino Acid Sequence
Antigens, Protozoan
Base Sequence
Carrier Proteins
Chemokine CXCL1
Chemokines, CXC
Chemotactic Factors
Duffy Blood-Group System
Endocytosis
Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Erythrocyte Membrane

Gene Expression

Genes

Genetic Predisposition to Disease

Growth Substances

Humans

Intercellular Signaling Peptides and Proteins

Interleukin-8

Source

Open in PubMed Open full text

Identifiers

PMID: 7699323
DOI: 10.1084/jem.181.4.1311
PMCID: PMC2191961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7699323-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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