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The Duffy antigen receptor for chemokines, ACKR 1,– ‘Jeanne DARC ’ of benign neutropenia

27 Dec 2018

Abstract excerpt

Benign neutropenia, observed in different ethnic groups, is the most common form of neutropenia worldwide. A specific single nucleotide polymorphism, rs2814778, located at the promoter of the ACKR1 (previously termed DARC) gene, which disrupts a binding site for the GATA1 erythroid transcription factor, resulting in a ACKR1-null phenotype, was found to serve as a predictor of low white blood cell and neutrophil...

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PMID: 30592023
DOI: 10.1111/bjh.15730

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