Article
Mechanisms of spontaneous mutation in DNA repair-proficient Escherichia coli.
Mutation research - 1 Jan 2000
Halliday J A, Glickman B W
Abstract excerpt
This paper describes the DNA sequence analysis of 729 independent spontaneous lacI- mutations. This total is comprised of 478 novel mutations and 251 previously described events, and therefore should allow a more comprehensive view of spontaneous mutation in Escherichia coli. The spectrum is dominated by a hotspot (71% of all events). Mutations at this site consist of related addition and deletion events...
Topics
- Base Sequence
- DNA Repair
- DNA, Bacterial
- Escherichia coli
- Frameshift Mutation
- Molecular Sequence Data
- Mutation