Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity of spontaneous DNA replication errors in single isogenic Escherichia coli cells.

Science advances - 1 Jun 2018

Woo Anthony C, Faure Louis, Dapa Tanja, Matic Ivan

Abstract excerpt

Despite extensive knowledge of the molecular mechanisms that control mutagenesis, it is not known how spontaneous mutations are produced in cells with fully operative mutation-prevention systems. By using a mutation assay that allows visualization of DNA replication errors and stress response transcriptional reporters, we examined populations of isogenic Escherichia coli cells growing under optimal conditions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to DNA Replication
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genes, Reporter

Share to Protein Biosynthesis

Share to Single-Cell Analysis

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 29938224
DOI: 10.1126/sciadv.aat1608
PMCID: PMC6010332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity of spontaneous DNA replication errors in single isogenic Escherichia coli cells.PMID 29938224Read ↗

Bacterial phenotypic heterogeneity in DNA repair and mutagenesis.Semantic proximity Read ↗

Determinants of spontaneous mutation in the bacterium Escherichia coli as revealed by whole-genome sequencing.Semantic proximity Read ↗

Mutational Signatures in Wild Type Escherichia coli Strains Reveal Predominance of DNA Polymerase Errors.Semantic proximity Read ↗

Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Semantic proximity Read ↗

Real-time monitoring of replication errors' fate reveals the origin and dynamics of spontaneous mutations.Semantic proximity Read ↗

Mutation dynamics and fitness effects followed in single cells.Semantic proximity Read ↗

A transient mutational burst occurs during yeast colony development.Semantic proximity Read ↗

Stationary phase mutagenesis in B. subtilis: a paradigm to study genetic diversity programs in cells under stress.Semantic proximity Read ↗

Is the occurrence of some spontaneous mutations directed by environmental challenges?Semantic proximity Read ↗

Use of high throughput sequencing to observe genome dynamics at a single cell level.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.