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Article

JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer.

Oncogene - 2 Jun 2016

Pangon L, Ng I, Giry-Laterriere M, Currey N, Morgan A, Benthani F, Tran P N, Al-Sohaily S, Segelov E, Parker B L, Cowley M J, Wright D C, St Heaps L, Carey L, Rooman I, Kohonen-Corish M R J

Abstract excerpt

The loss of β-catenin inhibitory components is a well-established mechanism of carcinogenesis but β-catenin hyperactivity can also be enhanced through its coactivators. Here we first interrogated a highly validated genomic screen and the largest repository of cancer genomics data and identified JRK as a potential new oncogene and therapeutic target of the β-catenin pathway. We proceeded to validate the oncogenic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26455321
DOI: 10.1038/onc.2015.347

Genes

JRK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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