Article
β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis.
Gut - 1 Sept 2011
van Veelen Wendy, Le Ngoc H, Helvensteijn Werner, Blonden Lau, Theeuwes Myrte, Bakker Elvira R M, Franken Patrick F, van Gurp Léon, Meijlink Frits, van der Valk Martin A, Kuipers Ernst J, Fodde Riccardo, Smits Ron
Abstract excerpt
Objective Deregulation of the Wnt signalling pathway by mutations in the Apc or β-catenin genes underlies colorectal carcinogenesis. As a result, β-catenin stabilises, translocates to the nucleus, and activates gene transcription. Intestinal tumours show a heterogeneous pattern of nuclear β-catenin, with the highest levels observed at the invasion front. Activation of receptor tyrosine kinases in these tumour...
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