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Article

Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat

7 Oct 2009

Abstract excerpt

The Wnt/beta-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of beta-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which beta-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have...

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PMID: 19808961
DOI: 10.1158/0008-5472.can-09-1704

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