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SP1 amplifies the effects of cellular proliferation via the Wnt/β-catenin pathway in colon development and cancer

2025-06-07

Abstract excerpt

Wnt/β-catenin signaling is a highly conserved pathway across multicellular organisms, playing a pivotal role in various cellular processes essential for development and tissue homeostasis. Aberrant activation of this pathway is a major driver of colorectal cancer (CRC). The transcription factor SP1 has been identified as a key component of the Wnt/β-catenin signaling pathway through its physical interaction with β...

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Literature Corpus work
1fb3913f-7306-528a-9201-5d5a0be4103a
DOI
10.1101/2025.06.05.658012
Open publication

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SP1 amplifies the effects of cellular proliferation via the Wnt/β-catenin pathway in colon development and cancerDOI 10.1101/2025.06.05.658012
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