Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer

Abstract excerpt

The genetic and epigenetic alterations occurring during the course of multistage colorectal carcinogenesis have been extensively studied in the last few decades. One of the most notable findings is that the great majority of colorectal cancers (>80%) have mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. Loss of functional APC protein results in activation of canonical Wnt/β-catanin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Mechanisms and Therapy
• Share to Cancer-related gene regulation
• Share to Wnt/β-catenin signaling in development and cancer