Article

MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3

2021-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Activation of Wnt signaling is among the earliest events of colon cancer development. It is achieved either via activating mutations in the CTNNB1 gene encoding β-catenin, the key transcription factor in the Wnt pathway, or most commonly by inactivating mutations in APC, a major β-catenin binding partner and negative regulator. However, our analysis of recent Pan Cancer Atlas data revealed that...

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Literature Corpus work: 98cd8c7b-f237-58d8-a6c6-cc67e41826a4
DOI: 10.1101/2021.07.26.453875

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