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Article

Role of CDK8 and β-catenin in colorectal adenocarcinoma

27 May 2010

Abstract excerpt

Colorectal adenocarcinoma is a major cause of morbidity and mortality. The Wnt/beta-catenin pathway plays an important role in colon cancers. However, relatively little is known about the regulatory mechanism of beta-catenin in colon cancers. CDK8 is a cyclin-dependent kinase (CDK) member of the mediator complex that couples transcriptional regulators to the basal transcriptional machinery, and is implicated in...

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PMID: 20514474
DOI: 10.3892/or_00000858

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