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Article

The kinase TNIK is an essential activator of Wnt target genes.

The EMBO journal - 4 Nov 2009

Mahmoudi Tokameh, Li Vivian S W, Ng Ser Sue, Taouatas Nadia, Vries Robert G J, Mohammed Shabaz, Heck Albert J, Clevers Hans

Abstract excerpt

Wnt signalling maintains the undifferentiated state of intestinal crypt/progenitor cells through the TCF4/beta-catenin-activating transcriptional complex. In colorectal cancer, activating mutations in Wnt pathway components lead to inappropriate activation of the TCF4/beta-catenin transcriptional...

Read the complete abstract on PubMed

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to beta Catenin
Share to Intestine, Small

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Serine-Threonine Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 19816403
DOI: 10.1038/emboj.2009.285
PMCID: PMC2776109

Genes

TNIK
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19816403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The kinase TNIK is an essential activator of Wnt target genes.PMID 19816403Read ↗

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The essential role of TNIK gene amplification in gastric cancer growthSemantic proximity Read ↗

A <i>Ctnnb1</i> enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epitheliaSemantic proximity Read ↗

Casein kinase I transduces Wnt signals.Semantic proximity Read ↗

Integrative ChIP-seq/Microarray Analysis Identifies a CTNNB1 Target Signature Enriched in Intestinal Stem Cells and Colon CancerSemantic proximity Read ↗

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