Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation

3 Jul 2018

Abstract excerpt

Epithelial-mesenchymal transition (EMT)-induced metastasis contributes to human colorectal cancer (CRC) progression, especially in advanced CRC. However, the underlying mechanism of β-catenin in this process is elusive. We identified that LIM domain kinase (LIMK)2 was progressively downregulated with tumor progression from precancerous lesions to advanced cancer. Gain- and loss-of-function assays revealed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal and Anal Carcinomas
Share to Colorectal Cancer Surgical Treatments
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29970879
DOI: 10.1038/s41419-018-0766-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocationPMID 29970879Read ↗

LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression.Semantic proximity Read ↗

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferationSemantic proximity Read ↗

LMNB2 promotes the progression of colorectal cancer by silencing p21 expressionSemantic proximity Read ↗

LIMK1: A Promising Prognostic and Immune Infiltration Indicator in Colorectal CancerSemantic proximity Read ↗

CLK3 promotes tumor proliferation by activating MYC signalingSemantic proximity Read ↗

LMNB2 Promotes the Progression of Colorectal Cancer by Silencing p21 ExpressionSemantic proximity Read ↗

miR-27b targets LIMK1 to inhibit growth and invasion of NSCLC cellsSemantic proximity Read ↗

ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signalingSemantic proximity Read ↗

A role for LIM kinase in cancer invasion.Semantic proximity Read ↗

Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancersSemantic proximity Read ↗

Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal TumorigenesisSemantic proximity Read ↗

RGL2 Drives the Metastatic Progression of Colorectal Cancer via Preventing the Protein Degradation of β-catenin and KRASSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.