The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus.

doi:10.1016/j.mce.2015.10.002

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Article

The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus.

Molecular and cellular endocrinology - 5 Jan 2016

Kaur Simranjeet, Mirza Aashiq H, Brorsson Caroline A, Fløyel Tina, Størling Joachim, Mortensen Henrik B, Pociot Flemming

Abstract excerpt

The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how...

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Identifiers

PMID: 26450151
DOI: 10.1016/j.mce.2015.10.002

Genes

ERBB3
INS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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