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ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

19 Jul 2019

Abstract excerpt

Abstract Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a...

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PMID: 31324766
DOI: 10.1038/s41467-019-10967-7

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