Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance.

Diabetes - 1 Jun 2025

Watson Taylor K, Rosen Aaron B I, Drow Travis, Medjo Jacob A, MacQuivey Matthew A, Ge Yan, Liggitt H Denny, Grosvenor Dane A, Dill-McFarland Kimberly A, Altman Matthew C, Concannon Patrick J, Buckner Jane H, Rawlings David J, Allenspach Eric J

Abstract excerpt

Genome-wide association studies have identified SH2B3 as an important non-MHC gene for islet autoimmunity and type 1 diabetes (T1D). In this study, we found a single SH2B3 haplotype significantly associated with increased risk for human T1D. Fine mapping has demonstrated the most credible causative variant is the single nucleotide rs3184504*T polymorphism in SH2B3. To better characterize the role of SH2B3 in T1D,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Cytokines

Share to Diabetes Mellitus, Type 1

Share to Immune Tolerance

Share to Islets of Langerhans

Share to Mice, Inbred NOD

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 40048557
DOI: 10.2337/db24-0655
PMCID: PMC12097456

Genes

SH2B3
CD4
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell-Intrinsic Immune Tolerance.PMID 40048557Read ↗

Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune toleranceSemantic proximity Read ↗

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.Semantic proximity Read ↗

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell toleranceSemantic proximity Read ↗

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunitySemantic proximity Read ↗

Rare <i>SH2B3</i> coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunitySemantic proximity Read ↗

UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-κB Signaling.Semantic proximity Read ↗

UBASH3A Interacts with PTPN22 to Regulate IL2 Expression and Risk for Type 1 Diabetes.Semantic proximity Read ↗

SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetesSemantic proximity Read ↗

Molecular-genetic characterization of common, noncoding UBASH3A variants associated with type 1 diabetes.Semantic proximity Read ↗

Genetic loss of SH2B3 in acute lymphoblastic leukemia.Semantic proximity Read ↗

Absence of SH2B3 mutation in nonobese diabetic mice.Semantic proximity Read ↗

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-αSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.