Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for two independent associations with type 1 diabetes at the 12q13 locus.

Genes and immunity - 1 Jan 2012

Keene K L, Quinlan A R, Hou X, Hall I M, Mychaleckyj J C, Onengut-Gumuscu S, Concannon P

Abstract excerpt

Genome-wide association studies have identified associations between type 1 diabetes and single-nucleotide polymorphisms (SNPs) at chromosome 12q13, surrounding the gene ERBB3. Our objective was to fine map this region to further localize causative variants. Re-sequencing identified more than 100 putative SNPs in an 80-kb region at 12q13. By genotyping 42 SNPs, spanning ∼214 kb, in 382 affected sibling pair type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 12
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ERBB3 gene

Share to Genetic Association Studies

Share to Genetic Loci

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Siblings

Source

Open in PubMed Open full text

Identifiers

PMID: 21850031
DOI: 10.1038/gene.2011.56
PMCID: PMC3285513

Genes

ERBB3
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for two independent associations with type 1 diabetes at the 12q13 locus.PMID 21850031Read ↗

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.Semantic proximity Read ↗

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.Semantic proximity Read ↗

The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus.Semantic proximity Read ↗

Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese.Semantic proximity Read ↗

Genetically dependent ERBB3 expression modulates antigen presenting cell function and type 1 diabetes risk.Semantic proximity Read ↗

Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.Semantic proximity Read ↗

Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q.Semantic proximity Read ↗

The rs2292239 polymorphism in ERBB3 gene is associated with risk for type 1 diabetes mellitus in a Brazilian population.Semantic proximity Read ↗

Identification of new genetic risk variants for type 2 diabetes.Semantic proximity Read ↗

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.Semantic proximity Read ↗

Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.Semantic proximity Read ↗

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.