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Article

The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs.

Diabetes - 1 Sept 2018

Kameswaran Vasumathi, Golson Maria L, Ramos-Rodríguez Mireia, Ou Kristy, Wang Yue J, Zhang Jia, Pasquali Lorenzo, Kaestner Klaus H

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is characterized by the inability of the insulin-producing β-cells to overcome insulin resistance. We previously identified an imprinted region on chromosome 14, the DLK1-MEG3 locus, as being downregulated in islets from humans with T2DM. In this study, using targeted epigenetic modifiers, we prove that increased methylation at the promoter of Meg3 in mouse βTC6 β-cells results in...

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Share to Calcium-Binding Proteins
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Intercellular Signaling Peptides and Proteins

Share to Islets of Langerhans

Share to Locus Control Region

Share to RNA, Long Noncoding

Share to Tissue Banks

Source

Open in PubMed Open full text

Identifiers

PMID: 30084829
DOI: 10.2337/db17-0682
PMCID: PMC6110314

Genes

DLK1
FOXA2
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs.PMID 30084829Read ↗

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