Article
A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2016
Fukaya Makiko, Brorsson Caroline A, Meyerovich Kira, Catrysse Leen, Delaroche Diane, Vanzela Emerielle C, Ortis Fernanda, Beyaert Rudi, Nielsen Lotte B, Andersen Marie L, Mortensen Henrik B, Pociot Flemming, van Loo Geert, Størling Joachim, Cardozo Alessandra K
Abstract excerpt
Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have identified the gene TNF-induced protein 3 (TNFAIP3), encoding for the zinc finger protein A20, as a susceptibility locus for T1D. A20 restricts NF-κB signaling and has strong antiapoptotic activities in β-cells. Although the role of A20 on NF-κB inhibition...
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