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Article

Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients.

Diabetes/metabolism research and reviews - 1 Mar 2026

Mertens Ina M, Keymeulen Bart, Gorus Frans K, Van De Casteele Mark

Abstract excerpt

AIM: The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non-HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D. Given the known molecular cooperation between ERBB2 and ERBB3 receptors in regulating cell function, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41782559
DOI: 10.1002/dmrr.70145
PMCID: PMC12961574

Genes

ERBB2
ERBB3
GSDMB
IKZF3
ORMDL3
IKZF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients.PMID 41782559Read ↗

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