A functional variant rs912304 for late-onset T1D risk contributes to islet dysfunction by regulating proinflammatory cytokine-responsive gene STXBP6 expression.

doi:10.1186/s12916-024-03583-w

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Article

A functional variant rs912304 for late-onset T1D risk contributes to islet dysfunction by regulating proinflammatory cytokine-responsive gene STXBP6 expression.

BMC medicine - 4 Sept 2024

Qian Yu, Chen Shu, Wang Yan, Zhang Yuyue, Zhang Jie, Jiang Liying, Dai Hao, Shen Min, He Yunqiang, Jiang Hemin, Yang Tao, Fu Qi, Xu Kuanfeng

Abstract excerpt

BACKGROUND: Our previous genome‑wide association studies (GWAS) have suggested rs912304 in 14q12 as a suggestive risk variant for type 1 diabetes (T1D). However, the association between this risk region and T1D subgroups and related clinical risk features, the underlying causal functional variant(s), putative candidate gene(s), and related mechanisms are yet to be elucidated. METHODS: We assessed the association...

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PMID: 39227839
DOI: 10.1186/s12916-024-03583-w
PMCID: PMC11373477

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