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Article

Genome Editing in Mice Using TALE Nucleases.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Wefers Benedikt, Brandl Christina, Ortiz Oskar, Wurst Wolfgang, Kühn Ralf

Abstract excerpt

Gene engineering for generating targeted mouse mutants is a key technology for biomedical research. Using TALENs as sequence-specific nucleases to induce targeted double-strand breaks, the mouse genome can be directly modified in zygotes in a single step without the need for embryonic stem cells. By embryo microinjection of TALEN mRNAs and targeting vectors, knockout and knock-in alleles can be generated fast and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26443225
DOI: 10.1007/978-1-4939-2932-0_17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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