Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contemporary approaches for modifying the mouse genome.

Physiological genomics - 15 Aug 2008

Adams David J, van der Weyden Louise

Abstract excerpt

The mouse is a premiere experimental organism that has contributed significantly to our understanding of vertebrate biology. Manipulation of the mouse genome via embryonic stem (ES) cell technology makes it possible to engineer an almost limitless repertoire of mutations to model human disease and assess gene function. In this review we outline recent advances in mouse experimental genetics and provide a "how-to"...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome
Share to Mice
Share to Mutagenesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 18559964
DOI: 10.1152/physiolgenomics.90242.2008
PMCID: PMC2519963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contemporary approaches for modifying the mouse genome.PMID 18559964Read ↗

Technical approaches for mouse models of human disease.Semantic proximity Read ↗

Functional genomics in the mouse.Semantic proximity Read ↗

The expanding role of mouse genetics for understanding human biology and disease.Semantic proximity Read ↗

Manipulating the mouse genome: approaches and applications.Semantic proximity Read ↗

Engineering mutations: deconstructing the mouse gene by gene.Semantic proximity Read ↗

Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology.Semantic proximity Read ↗

Modifying the mouse: design and desire.Semantic proximity Read ↗

Mouse mutagenesis: from gene to phenotype and back again.Semantic proximity Read ↗

Introduction: Strategies for developing genetically modified mice.Semantic proximity Read ↗

Mouse mutants and phenotypes: accessing information for the study of mammalian gene function.Semantic proximity Read ↗

Creating a "hopeful monster": mouse forward genetic screens.Semantic proximity Read ↗

Manipulating the mouse genome: implications for neurobiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.