Article
In vivo genome editing using a high-efficiency TALEN system.
Nature - 1 Nov 2012
Bedell Victoria M, Wang Ying, Campbell Jarryd M, Poshusta Tanya L, Starker Colby G, Krug Randall G, Tan Wenfang, Penheiter Sumedha G, Ma Alvin C, Leung Anskar Y H, Fahrenkrug Scott C, Carlson Daniel F, Voytas Daniel F, Clark Karl J, Essner Jeffrey J, Ekker Stephen C
Abstract excerpt
The zebrafish (Danio rerio) is increasingly being used to study basic vertebrate biology and human disease with a rich array of in vivo genetic and molecular tools. However, the inability to readily modify the genome in a targeted fashion has been a bottleneck in the field. Here we show that improvements in artificial transcription activator-like effector nucleases (TALENs) provide a powerful new approach for...
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