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Article

Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology.

Genome biology - 28 Feb 2018

Burgio Gaetan

Abstract excerpt

The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles.

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Source

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Identifiers

PMID: 29490686
DOI: 10.1186/s13059-018-1409-1
PMCID: PMC5831610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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