Article
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases.
Nucleic acids research - 1 Jun 2013
Qiu Zhongwei, Liu Meizhen, Chen Zhaohua, Shao Yanjiao, Pan Hongjie, Wei Gaigai, Yu Chao, Zhang Long, Li Xia, Wang Ping, Fan Heng-Yu, Du Bing, Liu Bin, Liu Mingyao, Li Dali
Abstract excerpt
Transcription activator-like effector nucleases (TALENs) are a powerful new approach for targeted gene disruption in various animal models, but little is known about their activities in Mus musculus, the widely used mammalian model organism. Here, we report that direct injection of in vitro trans...
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