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Highly Efficient Targeted Mutagenesis in Mice Using TALENs

27 Aug 2013

Abstract excerpt

Targeted mouse mutants are instrumental for the analysis of gene function in health and disease. We recently provided proof-of-principle for the fast-track mutagenesis of the mouse genome, using transcription activator-like effector nucleases (TALENs) in one-cell embryos. Here we report a routine procedure for the efficient production of disease-related knockin and knockout mutants, using improved TALEN mRNAs...

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PMID: 23979585
DOI: 10.1534/genetics.113.156570

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