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Article

A TALE of two nucleases: gene targeting for the masses?

Zebrafish - 1 Sept 2011

Clark Karl J, Voytas Daniel F, Ekker Stephen C

Abstract excerpt

Genome editing appears poised to enter an exciting new era. Targeted double-stranded breaks due to custom restriction enzymes are powerful nucleating events for the induction of local changes in the genome. The zinc finger nuclease (ZFN) platform established the potential of this approach for the zebrafish, but access to high quality reagents has been a major bottleneck for the field. However, two groups recently...

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Identifiers

PMID: 21929364
DOI: 10.1089/zeb.2011.9993
PMCID: PMC3174730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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