Article

New human chromosomal safe harbor sites for genome engineering with CRISPR/Cas9, TAL effector and homing endonucleases

2018-08-20

Abstract excerpt

Safe Harbor Sites (SHS) are genomic locations where new genes or genetic elements can be introduced without disrupting the expression or regulation of adjacent genes. We have identified 35 potential new human SHS in order to substantially expand SHS options beyond the three widely used canonical human SHS, AAVS1, CCR5 and hROSA26 . All 35 potential new human SHS and the three canonical sites were assessed for SH...

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Literature Corpus work: c484da49-6a2d-5eb4-925e-287408000b6d
DOI: 10.1101/396390

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