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A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

25 Sept 2015

Abstract excerpt

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that is down regulated in human seminoma. Depletion of Gravin correlates with an increased mitotic index and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26406118
DOI: 10.7554/elife.09384

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