Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?

24 Dec 2012

Abstract excerpt

Correct alignment of the mitotic spindle during cell division is crucial for cell fate determination, tissue organization, and development. Mutations causing brain diseases and cancer in humans and mice have been associated with spindle orientation defects. These defects are thought to lead to an imbalance between symmetric and asymmetric divisions, causing reduced or excessive cell proliferation. However, most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23266953
DOI: 10.1083/jcb.201209015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?PMID 23266953Read ↗

The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization.Semantic proximity Read ↗

Mitotic spindle misorientation in cancer--out of alignment and into the fire.Semantic proximity Read ↗

Spindle orientation and asymmetric cell fate.Semantic proximity Read ↗

Mitotic spindle orientation in epithelial homeostasis and plasticitySemantic proximity Read ↗

Mechanisms of minor pole-mediated spindle bipolarization in human oocytes.Semantic proximity Read ↗

The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Semantic proximity Read ↗

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1Semantic proximity Read ↗

Mitotic chromosome alignment is required for proper nuclear envelope reassemblySemantic proximity Read ↗

The centrosome orientation checkpoint is germline stem cell specific and operates prior to the spindle assembly checkpoint in Drosophila testis.Semantic proximity Read ↗

The Tubulin Code in Mitosis and CancerSemantic proximity Read ↗

Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproductionSemantic proximity Read ↗

Spindle Microtubule Dysfunction and Cancer PredispositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.