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Article

mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.

Nature communications - 24 Jun 2020

Bonucci Martina, Kuperwasser Nicolas, Barbe Serena, Koka Vonda, de Villeneuve Delphine, Zhang Chi, Srivastava Nishit, Jia Xiaoying, Stokes Matthew P, Bienaimé Frank, Verkarre Virginie, Lopez Jean Baptiste, Jaulin Fanny, Pontoglio Marco, Terzi Fabiola, Delaval Benedicte, Piel Matthieu, Pende Mario

Abstract excerpt

mTOR activation is essential and sufficient to cause polycystic kidneys in Tuberous Sclerosis Complex (TSC) and other genetic disorders. In disease models, a sharp increase of proliferation and cyst formation correlates with a dramatic loss of oriented cell division (OCD). We find that OCD distortion is intrinsically due to S6 kinase 1 (S6K1) activation. The concomitant loss of S6K1 in Tsc1-mutant mice restores...

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Identifiers

PMID: 32581239
DOI: 10.1038/s41467-020-16978-z
PMCID: PMC7314806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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