Article

Male mammalian meiosis and spermiogenesis is critically dependent on the shared functions of the katanins KATNA1 and KATNAL1

2022-11-12

Abstract excerpt

<h4>Summary</h4> Katanin microtubule severing enzymes are potent M-phase regulators in oocytes and somatic cells. How the complex, and evolutionarily critical, male mammalian meiotic spindle is sculpted remains unknown. Here, using multiple single and double gene knockout mice, we reveal that the canonical katanin A-subunit, KATNA1, and its close paralogue, KATNAL1, together execute multiple aspects of meiosis. W...

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Literature Corpus work: 57b0df94-2bc2-512d-ad92-e6a7ea003d5f
DOI: 10.1101/2022.11.11.516072

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