Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jan 2002

Merker Robert J, Klein Hannah L

Abstract excerpt

Multiple genetic pathways have been shown to regulate life span and aging in the yeast Saccharomyces cerevisiae. Here we show that loss of a component of the RNA polymerase II complex, Hpr1p, results in a decreased life span. Although hpr1Delta mutants have an increased rate of recombination within the ribosomal DNA (rDNA) array, this is not accompanied by an increase in extrachromosomal rDNA circles (ERCs)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Fungal
Share to DNA Helicases
Share to DNA, Ribosomal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to RecQ Helicases

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 11756539
DOI: 10.1128/MCB.22.2.421-429.2002
PMCID: PMC139738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.PMID 11756539Read ↗

Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in DNA replication genes reduce yeast life span.Semantic proximity Read ↗

Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity.Semantic proximity Read ↗

Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations.Semantic proximity Read ↗

Reproductive potential and instability of the rDNA region of the Saccharomyces cerevisiae yeast: Common or separate mechanisms of regulation?Semantic proximity Read ↗

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.Semantic proximity Read ↗

Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol.Semantic proximity Read ↗

Comprehensive synthetic genetic array analysis of alleles that interact with mutation of the <i>Saccharomyces cerevisiae</i> RecQ helicases Hrq1 and Sgs1Semantic proximity Read ↗

The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase.Semantic proximity Read ↗

Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.Semantic proximity Read ↗

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.