Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability.

Molecular and cellular biology - 1 Apr 2014

Allen Stephanie, Martinez Sandra L, Putnam Christopher D, Kolodner Richard D

Abstract excerpt

Errors during DNA replication are one likely cause of gross chromosomal rearrangements (GCRs). Here, we analyze the role of RNase H2, which functions to process Okazaki fragments, degrade transcription intermediates, and repair misincorporated ribonucleotides, in preventing genome instability. The results demonstrate that rnh203 mutations result in a weak mutator phenotype and cause growth defects and synergistic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Genomic Instability

Share to Recombination, Genetic

Share to Ribonuclease H

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 24550002
DOI: 10.1128/MCB.00960-13
PMCID: PMC3993591

Genes

RAD51
TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instability.PMID 24550002Read ↗

Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity.Semantic proximity Read ↗

RNase H2 roles in genome integrity revealed by unlinking its activities.Semantic proximity Read ↗

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read ↗

Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phaseSemantic proximity Read ↗

Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivoSemantic proximity Read ↗

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.Semantic proximity Read ↗

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.Semantic proximity Read ↗

DNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures.Semantic proximity Read ↗

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescueSemantic proximity Read ↗

RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability.Semantic proximity Read ↗

Arabidopsis thaliana RNase H2 deficiency counteracts the needs for the WEE1 checkpoint kinase but triggers genome instability.Semantic proximity Read ↗

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.