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Article

HLA DNA sequence variation among human populations: molecular signatures of demographic and selective events.

PloS one - 1 Feb 2011

Buhler Stéphane, Sanchez-Mazas Alicia

Abstract excerpt

Molecular differences between HLA alleles vary up to 57 nucleotides within the peptide binding coding region of human Major Histocompatibility Complex (MHC) genes, but it is still unclear whether this variation results from a stochastic process or from selective constraints related to functional differences among HLA molecules. Although HLA alleles are generally treated as equidistant molecular units in...

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Identifiers

PMID: 21408106
DOI: 10.1371/journal.pone.0014643
PMCID: PMC3051395

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