Article

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens

2021-01-12

Abstract excerpt

Allelic diversity of HLA class II genes may help maintain humoral immunity against infectious diseases. We investigated the relative contribution of specific HLA class II alleles, haplotypes and genotypes on the variation of antibody responses to a variety of common pathogens in a cohort of 800 adults representing the general Arab population. We found that classical HLA class II gene heterozygosity confers a selec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b811f66-d9e9-5a83-8cf5-7f6233f4b453
DOI: 10.1101/2021.01.11.426296

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogensDOI 10.1101/2021.01.11.426296Read

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens.Semantic proximity Read

HLA Diversity in Saudi Population: High Frequency of Homozygous HLA Alleles and HaplotypesSemantic proximity Read

Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: Relevance in infectious diseases and vaccination studies in human populations.Semantic proximity Read

Pathogen-driven selection and worldwide HLA class I diversity.Semantic proximity Read

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.Semantic proximity Read

Human Leukocyte Antigen Diversity: A Southern African Perspective.Semantic proximity Read

Untangling associations between immunoglobulin genotypes, repertoires and function.Semantic proximity Read

Immunoglobulin germline gene variation and its impact on human disease.Semantic proximity Read

Distinct evolutionary strategies of human leucocyte antigen loci in pathogen-rich environments.Semantic proximity Read

The human antibody repertoire to infectious agents: implications for disease pathogenesis.Semantic proximity Read

Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection.Semantic proximity Read

Role of Human Leukocyte Antigen Class II in Antibody-Mediated Skin Disorders.Semantic proximity Read