Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of HLA class I functional divergence on HIV control.

Science (New York, N.Y.) - 19 Jan 2024

Viard Mathias, O'hUigin Colm, Yuki Yuko, Bashirova Arman A, Collins David R, Urbach Jonathan M, Wolinsky Steven, Buchbinder Susan, Kirk Gregory D, Goedert James J, Michael Nelson L, Haas David W, Deeks Steven G, Walker Bruce D, Yu Xu, Carrington Mary

Abstract excerpt

Heterozygosity of Human leukocyte antigen (HLA) class I genes is linked to beneficial outcomes after HIV infection, presumably through greater breadth of HIV epitope presentation and cytotoxic T cell response. Distinct allotype pairs, however, differ in the extent to which they bind shared sets of peptides. We developed a functional divergence metric that measures pairwise complementarity of allotype-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Heterozygote

Share to HIV Infections

Share to HLA-B Antigens

Share to Peptides

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 38236978
DOI: 10.1126/science.adk0777
PMCID: PMC11395297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of HLA class I functional divergence on HIV control.PMID 38236978Read ↗

HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.Semantic proximity Read ↗

Co-operative additive effects between HLA alleles in control of HIV-1.Semantic proximity Read ↗

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response.Semantic proximity Read ↗

Associations of functional human leucocyte antigen class I groups with HIV viral load in a heterogeneous cohort.Semantic proximity Read ↗

Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection.Semantic proximity Read ↗

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy.Semantic proximity Read ↗

Like Wings of a Bird: Functional Divergence and Complementarity between HLA-A and HLA-B Molecules.Semantic proximity Read ↗

HIV-1 diversity versus HLA class I polymorphism.Semantic proximity Read ↗

Associations of functional HLA class I groups with HIV viral load in a heterogeneous cohortSemantic proximity Read ↗

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.Semantic proximity Read ↗

HLA-B evolutionary divergence is associated with outcomes after SARS-CoV-2 infection.Semantic proximity Read ↗

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.