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Article

Computational prediction of MHC II-antigen binding supports divergent allele advantage and explains trans-species polymorphism.

Evolution; international journal of organic evolution - 1 Aug 2011

Lenz Tobias L

Abstract excerpt

The major histocompatibility complex (MHC), coding for antigen presenting molecules of the adaptive immune system, represents one of the most polymorphic regions in the vertebrate genome. The exceptional polymorphism, which is potentially maintained by balancing selection under host-parasite coevolution, comprises excessive sequence divergence among alleles as well as ancient allelic lineages that predate species...

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PMID: 21790583
DOI: 10.1111/j.1558-5646.2011.01288.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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