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Article

A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric.

Human molecular genetics - 15 Jan 2013

Bronson Paola G, Mack Steven J, Erlich Henry A, Slatkin Montgomery

Abstract excerpt

Balancing selection has maintained human leukocyte antigen (HLA) allele diversity, but it is unclear whether this selection is symmetric (all heterozygotes are comparable and all homozygotes are comparable in terms of fitness) or asymmetric (distinct heterozygote genotypes display greater fitness than others). We tested the hypothesis that HLA is under asymmetric balancing selection in populations by estimating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23065702
DOI: 10.1093/hmg/dds424
PMCID: PMC3526157

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