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Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Immunology and cell biology - 1 Mar 2016

Ramsbottom Kelly M, Sacirbegovic Faruk, Hawkins Edwin D, Kallies Axel, Belz Gabrielle T, Van Ham Vanessa, Haynes Nicole M, Durrant Michael J, Humbert Patrick O, Russell Sarah M, Oliaro Jane

Abstract excerpt

Lethal giant larvae-1 (Lgl-1) is an evolutionary conserved protein that regulates cell polarity in diverse lineages; however, the role of Lgl-1 in the polarity and function of immune cells remains to be elucidated. To assess the role of Lgl-1 in T cells, we generated chimeric mice with a hematopoietic system deficient for Lgl-1. Lgl-1 deficiency did not impair the activation or function of peripheral CD8(+) T...

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PMID: 26391810
DOI: 10.1038/icb.2015.82

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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