Article
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Latchman Yvette E, Liang Spencer C, Wu Yin, Chernova Tatyana, Sobel Raymond A, Klemm Martina, Kuchroo Vijay K, Freeman Gordon J, Sharpe Arlene H
Abstract excerpt
Both positive and negative regulatory roles have been suggested for the B7 family member PD-L1(B7-H1). PD-L1 is expressed on antigen-presenting cells (APCs), activated T cells, and a variety of tissues, but the functional significance of PD-L1 on each cell type is not yet clear. To dissect the functions of PD-L1 in vivo, we generated PD-L1-deficient (PD-L1(-/-)) mice. CD4(+) and CD8(+) T cell responses were...
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