Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses

17 Aug 2010

Abstract excerpt

Cell-mediated adaptive immunity is very important in tumor immune surveillance and tumor vaccination. However, the genetic program underlying an effective adaptive antitumor immunity is elusive. T-bet and Eomesodermin (Eomes) have been suggested to be master regulators of Th1 cells and CD8(+) T cells. However, whether they are important for T cell-mediated antitumor immunity is controversial. In this paper, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20713880
DOI: 10.4049/jimmunol.1000749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune ResponsesPMID 20713880Read ↗

EOMES and IL-10 regulate anti-tumor activity of PD-1 <sup>+</sup> CD4 <sup>+</sup> T-cells in B-cell Non-Hodgkin lymphomaSemantic proximity Read ↗

Eomes+T-betlow CD8+ T Cells Are Functionally Impaired and Are Associated with Poor Clinical Outcome in Patients with Acute Myeloid LeukemiaSemantic proximity Read ↗

Natural Innate and Adaptive Immunity to CancerSemantic proximity Read ↗

Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responsesSemantic proximity Read ↗

T-BET and EOMES sustain mature human NK cell identity and antitumor functionSemantic proximity Read ↗

TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responsesSemantic proximity Read ↗

T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.Semantic proximity Read ↗

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer ImmunitySemantic proximity Read ↗

Immune surveillance of tumorsSemantic proximity Read ↗

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.Semantic proximity Read ↗

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells.Semantic proximity Read ↗

Current advances in cancer vaccines targeting NY-ESO-1 for solid cancer treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.