Article
PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2009
Parekh Vrajesh V, Lalani Saif, Kim Sungjune, Halder Ramesh, Azuma Miyuki, Yagita Hideo, Kumar Vipin, Wu Lan, Kaer Luc Van
Abstract excerpt
Invariant NKT (iNKT) cells recognize glycolipid Ags, such as the marine sponge-derived glycosphingolipid alpha-galactosylceramide (alphaGalCer) presented by the CD1d protein. In vivo activation of iNKT cells with alphaGalCer results in robust cytokine production, followed by the acquisition of an anergic phenotype. Here we have investigated mechanisms responsible for the establishment of alphaGalCer-induced iNKT...
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